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Hydroquinone, Mometasone & Tretinoin Cream
Introduction
Hydroquinone, Mometasone, and Tretinoin cream is a triple-action topical dermatological formulation widely used for treating pigmentation disorders, including melasma, dark spots, uneven skin tone, and related skin concerns. This combination harnesses the unique effects of:
Hydroquinone – A potent depigmenting agent that inhibits melanin production.
Tretinoin – A retinoid that accelerates skin cell turnover to promote renewal.
Mometasone Furoate – A corticosteroid that reduces inflammation, redness, and irritation.
This combination is not a cosmetic but a prescription-strength dermatological cream, and its use should be medically supervised due to the active nature of its ingredients.
Dermapolis – Company Overview
Dermapolis is an Indian derma-pharmaceutical company specializing in advanced skincare solutions and dermatological products for a wide range of skin concerns including pigmentation, inflammation, and infections. Their formulations are scientifically developed and dermatologist-tested, designed for safe and effective treatment when used as directed. Dermapolis
Company Focus
Offers creams, lotions, tablets, and sunscreens targeted at various skin conditions.
Emphasizes scientifically backed derma solutions aimed at improving skin health with quality and safety.
Markets derma products through PCD (Propaganda Cum Distribution) franchise networks across India.
One of Dermapolis’s key products in the pigmentation category is:
👉 QINOTWIST™ — a formulation containing Hydroquinone 2% + Mometasone 0.1% + Tretinoin 0.025% in a cream base.
How the Combination Works
1. Hydroquinone (2%)
Inhibits melanin production by blocking tyrosinase activity.
Helps lighten dark patches like freckles, age spots, and melasma.
2. Tretinoin (0.025%)
A vitamin-A derivative that accelerates cellular turnover.
Improves skin texture, promotes fresh skin renewal, and enhances penetration of hydroquinone.
3. Mometasone Furoate (0.1%)
A medium-strength corticosteroid that reduces inflammation and irritation caused by the other active agents.
Helps improve tolerability, especially in sensitive or reactive skin.
This combination works synergistically: hydroquinone and tretinoin target pigmentation while mometasone keeps inflammatory responses under control — important because retinoids can temporarily irritate skin.
Common Indications
The cream is typically indicated for dermatological use under medical supervision for:
Melasma / Chloasma
Hyperpigmentation from acne scars
Sun-induced pigmentation
Uneven skin tone and dark spots
It is designed for short-term use — prolonged application is not recommended without close dermatology oversight.
Usage Guidelines
✔ Apply a thin layer only to affected areas.
✔ Best used once daily at night, as Tretinoin increases sun sensitivity.
✔ Always pair with broad-spectrum sunscreen during the day (SPF 30 or higher).
✔ Avoid contact with eyes, lips, and mucous membranes.
✔ Discontinue if you notice severe redness or allergic reactions.
Medical guidance is essential, as improper use can lead to adverse effects.
Safety & Side Effects
While effective, this combination can cause side effects, particularly if misused:
Common reactions
Mild burning, redness, stinging, dryness, or peeling.
Potential risks
Increased photosensitivity — risk of sunburn without protection.
Skin thinning or fragility with prolonged corticosteroid use.
Possible allergic reactions in sensitive individuals.
➡️ Using the cream strictly under dermatological direction helps minimize risks and ensures correct duration and frequency.
Why Dermapolis’s Formulation Matters
Dermapolis promotes formulations such as Qinotwist™ with a focus on:
✅ Clinically developed, dermatologist-tested ingredients
✅ Dermatology-grade products rather than cosmetic over-the-counter mixes
✅ Quality assurance and safety standards
✅ Availability through professional medical and PCD franchise channels rather than consumer drug stores Dermapolis
This positions Dermapolis’s version of the hydroquinone–mometasone–tretinoin cream as a therapeutic dermatology product intended for monitored clinical use, not casual cosmetic use.
Conclusion
Hydroquinone, Mometasone & Tretinoin cream is a powerful dermatological treatment for pigmentation issues, combining three actives that work together effectively when used appropriately. Dermapolis, as a derma-pharma company, offers this combination in a professionally formulated product (e.g., Qinotwist™), emphasizing safety, dermatologist testing, and clinical effectiveness. However, due to the strength and potential side effects, this cream should only be used under medical supervision to ensure maximum benefit and safety.