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All About Deflazacort Tablet
Introduction
Deflazacort is a synthetic corticosteroid (a steroid) medication used to treat a variety of medical conditions that involve inflammation and abnormal immune responses. It acts by reducing the production of substances in the body that cause inflammation and immune system overactivity—helping manage symptoms and disease progression.
Doctors often prescribe Deflazacort when a strong anti-inflammatory or immunosuppressive therapy is needed, such as in autoimmune diseases, allergic reactions, severe inflammatory disorders, and specific muscular conditions like Duchenne Muscular Dystrophy (DMD).
What Is Deflazacort and How It Works
Deflazacort belongs to a class of drugs called glucocorticoids, which are similar to cortisol — a hormone produced naturally by your body’s adrenal glands. It works by:
Suppressing inflammation and swelling in body tissues.
Reducing immune system activity when it is excessively active or attacking the body’s own cells.
This makes it useful for conditions where overactive immunity or inflammation causes harm — for example, joint swelling in arthritis or muscle degeneration in DMD.
Key Uses of Deflazacort Tablet
Deflazacort is prescribed for several medical conditions, including:
1. Duchenne Muscular Dystrophy (DMD)
This is a genetic muscular condition that leads to progressive muscle weakness. Deflazacort slows progression, helps preserve strength, and supports mobility in affected individuals.
2. Autoimmune and Inflammatory Diseases
It’s used in diseases where the immune system mistakenly attacks body tissues — such as rheumatoid arthritis, lupus, inflammatory bowel disease, and vasculitis.
3. Allergic and Respiratory Conditions
Sometimes prescribed for severe allergies, asthma exacerbations, or chronic obstructive pulmonary disease (COPD) flare-ups to reduce airflow obstruction and inflammation.
4. Skin Disorders and Severe Dermatitis
Although topical treatments are first-line in mild cases, tablets may be used for widespread or severe eczema, psoriasis, or allergic dermatitis.
5. Other Uses
Severe allergic responses
Autoimmune eye diseases
Certain transplant protocols (to reduce rejection)
Other inflammation-driven illnesses as determined by a physician
How to Use Deflazacort Tablet
Always take Deflazacort exactly as prescribed by your doctor. Typical administration details:
Taken orally with or without food — preferably at the same time each day to maintain consistent blood levels.
Do not crush or chew tablets unless instructed.
For children and weight-based doses, dosage must be carefully adjusted by a physician.
Typical Dosage Guidelines
Dosage of Deflazacort varies widely depending on:
The condition being treated
The severity of disease
Age and weight of the patient
Response to therapy
For Duchenne Muscular Dystrophy, a commonly used dose (for adults and children over 2) is about 0.9 mg per kg of body weight once daily, but this must be tailored by a clinician.
Important: Never self-adjust or stop the dose suddenly. Stopping abruptly can lead to serious withdrawal symptoms.
Possible Side Effects
Because Deflazacort impacts immune and metabolic functions, it may cause a range of side effects:
Common Side Effects
Weight gain and increased appetite
Mood changes
Increased urination
Upper respiratory symptoms (cough, throat irritation)
Facial hair growth or skin changes
Changes in fat distribution (e.g., “moon face”)
Less Common / Serious Side Effects
Changes in blood sugar (hyperglycemia)
Weak bones (osteoporosis)
Eye issues — glaucoma or cataracts
Increased risk of infections
Growth slowing in children
Severe allergic reactions including rash or breathing difficulty
If you notice severe symptoms — such as difficulty breathing, swelling, severe mood changes, vision changes, or signs of infection — seek medical help immediately.
Precautions and Important Advice
Before Starting Treatment
Tell your doctor if you:
Have diabetes, heart, kidney, or liver problems
Have a history of tuberculosis, infections, or osteoporosis
Are pregnant or planning a pregnancy
Are breastfeeding
Vaccination
Live vaccines should generally be avoided during treatment and for several weeks after stopping Deflazacort, as the immune response may be compromised.
Alcohol & Diet
Avoid alcohol and grapefruit or grapefruit juice — they may increase side effects.
Infection Risk
Because Deflazacort suppresses the immune system, stay away from people who are ill and report infections to your doctor early.
Stopping the Medicine
Never stop suddenly. Your doctor will taper the dose to prevent adrenal insufficiency and withdrawal effects.
About Dermapolis Company
Dermapolis is an Indian derma PCD pharmaceutical company that offers a portfolio of dermatology-focused products, including tablets & capsules like Deflazacort formulations.
They focus on dermatologically tested, scientifically formulated products designed to support skin health and systemic conditions where dermatologic therapy is involved.
Dermatologists may trust such products for safe, effective skin-related treatment protocols, often as part of a broader health plan.
Dermapolis offers options for PCD pharma franchise and distribution across India, emphasizing quality and innovation.
You can contact Dermapolis through their official channels for product specifics, franchise details, or prescribing information if they supply Deflazacort tablets or related therapies.
Summary
Deflazacort Tablet is a powerful corticosteroid medicine used to treat inflammatory, autoimmune, and certain genetic muscle disorders — most notably Duchenne Muscular Dystrophy. It must be taken only under medical supervision due to potential side effects and the need for precise dosing based on individual health status.
Precautions, careful monitoring, and professional guidance are essential to getting the best therapeutic outcomes with minimal risk. Its role in systemic inflammation suppression makes it a versatile but potent treatment option in many clinical settings.